In contrast, in human glioblastoma (GBM) cell lines CA did not down-regulate the PI3K/AKT pathway, whereas it induced proteasomal down-regulation of Retinoblastoma, Cyclin B1, SOX2 and GFAP and cell cycle arrest with only a minor induction of apoptosis [23]. This evidence concerns the gene AKT1 and glioblastoma.