BRAF and metastatic melanoma: The first of these, trametinib, demonstrated an ORR of 22% vs. 8% for dacarbazine, and a median PFS of 4.8 months vs. 1.5 months (HR 0.45; 95% CI, 0.33–0.63; P < 0.001) in BRAF-mutant metastatic melanoma in the phase III METRIC trial [16].