Furthermore, published evidence has shown that antigen-specific spontaneous immune response are beneficial for different solid malignancies—MSLN in pancreatic cancer [32, 33], CA125 in ovarian cancer [34], and WT1 in mesothelioma [41]—and has driven us to explore the expression of these antigens on MPM. The gene discussed is MSLN; the disease is familial pancreatic carcinoma.