Next we queried Kaplan-Meier plotter (a database that encompasses gene expression and survival data of genes in 4,142 breast cancer patients where data have been downloaded from GEO, EGA, and TCGA databases) [77] to address whether overexpression of E2Fs and several mitotic regulators including BubR1, Hec1, Nek2, Mps1/TTK, and Sgo1 are correlated with survival outcomes. The gene discussed is BUB1B; the disease is breast cancer.