Kalacc et.al [17] observed acetylated histone H3 in diffuse large B cell lymphoma (DLBCL) cell lines increased after 24h and 48h treatment with panobinostat combining decitabine compared to either drug alone, which suggests decitabine can enhance the activity of HDAC inhibitor. This evidence concerns the gene HDAC9 and diffuse large B-cell lymphoma.