The 39 ASOs that change BIM splicing (Supplementary Figure 3A) were next tested in the imatinib-resistant CML cell line KCL22, which is heterozygous for the 2,903-bp deletion allele, and expresses BIM transcripts with a higher E3/E4 ratio compared to K562 (Supplementary Figure 2A). The gene discussed is BCL2L11; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.