We found that high expression of PTP4A2 was an independent prognostic factor for poor OS of NPC patients in both validation cohort and overall cases (HR=2.784,95%CI: 1.815-4.269, P<0.001; HR=5.065, 95%CI: 3.490-7.351, P<0.001, respectively, Table 5) as evidenced by multivariate analysis. Here, PTP4A2 is linked to nasopharyngeal carcinoma.