JUN and myelodysplastic syndrome: To address the importance of JNK signaling in WFA-induced apoptosis of MDS-L cells, we employed a well-characterized selective covalent JNK inhibitor [37], JNK-IN-8, and the well-known antioxidant NAC.JNK-IN-8 pretreatment inhibited WFA-induced C-JUN phosphorylation (Figure 6A).