To investigate the association between clinico-histopathological features and miRNA expression levels, we found interesting links between features of carcinomas with worse prognosis such as LNM presence, G3, HR negative and HER2 amplified status, high Ki-67 expression and CTC presence, and down-regulation of the selected miRNAs of miR-17/92 cluster. This evidence concerns the gene MKI67 and carcinoma.