In order to find a potential inhibitor of this interaction, we performed a screening of compounds by BRET experiments and found one candidate, a derivative of phenazine, compound 14, that was not a DNA intercaling agent and inhibited Hsp27/eIF4E interaction leading to cell viability inhibition and increase of apoptosis of castration-resistant prostate cancer cells. Here, EIF4E is linked to Familial prostate cancer.