Many approaches over the years have been used to try to inhibit eIF4E functions, particularly the use of small molecule inhibitors that can disrupt the eIF4E/eIF4G interaction, the use of cap analogs to directly target the eIF4E cap-binding site, or ASOs that have been proven to be efficient in reducing the expression level of eIF4E and are tested in many clinical trials in prostate cancer patients [12]. The gene discussed is EIF4E; the disease is prostate carcinoma.