To determine the role of SIRT7 in PCa, we analyzed the expression of SIRT7 and the acetylation of H3K18 in PCa cell lines (two androgen-dependent cell lines: LNCaP and 22RV and two androgen-independent cells lines DU145 and PC3) and one normal prostate epithelial cell line P69. This evidence concerns the gene SIRT7 and posterior cortical atrophy.