CUL4B and neoplasm: At the 10th day after inoculation, the tumor volume in the si-CUL4B group was reduced in comparison to the siRNA-NC and control groups (all P < 0.05), the tumor volume in the CUL4B group was larger than the control group (P < 0.05), and no tumor volume differences were found among the siRNA-NC and control groups (all P > 0.05) (Figure 8A).