In fact, in addition to the markers CD4 and CD8, the major difference between CD4+ and CD8+ T cells is the corresponding molecule to the T cell receptor, that is, major histocompatibility complex II (MHC-II) on antigen-presentation cells, and MHC-I on nucleated cells (in this case, PCa cells) [19]. Here, CD4 is linked to posterior cortical atrophy.