In here, Tregs expressing CTLA-4, ICOS, ENTPD1, CD45RA and PD-1 were the majority among tumoral Tregs and the so called effector Tregs, CD25hiFOXP3hiCD45RA- highly suppressive cells, were the most represented among tumor Tregs tissue derived [13]. Here, PDCD1 is linked to neoplasm.