Further investigations of the clinical impact of GLO1 copy number in patients with GEP-NET will require multicentre studies with relevant numbers of patients who ideally had surgical on repeated occasions; and patients with surgical samples from tumour resection and subsequent treatment with STZ-based chemotherapy, mTOR inhibitors or tyrosine kinase inhibitors in case of a future relapse or progression. This evidence concerns the gene GLO1 and neoplasm.