However, even if a relevant number of cases could be achievable in a large international multi-centre setting, results of GLO1 CNV may be influenced by not rarely observed changes in tumour biology of GEP-NET in the chronic setting, and by influences of the treatment with cytotoxic agents per se, i.e. by increasing cellular MG concentrations and related cytotoxicity as part of their mechanism of action [12, 21, 26]. Here, GLO1 is linked to neoplasm.