TP53 and cervical carcinoma: The p53-pathway, which is a major driver of cell cycle arrest and apoptosis [27], was consistently activated in A2780 and A2780cis cells, which is in accordance to our in vitro experiments on 5-FdU-ECyd mediated apoptosis and is also in line with previous studies, reporting that 5-FdU-ECyd induces apoptosis and G1-arrest in cervical cancer cells in vitro [12].