RT-qPCR and Western blot analysis of tumor cells derived from EμSRα-tTA;tet-o-MYC transgenic mice indicate that DNMT3B expression levels were elevated in MYC-driven T-ALL compared to normal spleen from wild-type C57BL/6J mice (Figure 1A, 1B, 1C and Supplementary Figure 1). This evidence concerns the gene MYC and acute lymphoblastic leukemia.