To unravel the role of DNA methyltransferases (DNMTs) in MYC-driven hematopoietic malignancies, we performed expression profiling for DNMT1, DNMT3A and DNMT3B comparing MYC-driven T-ALL and Burkitt’s lymphoma cells to non-malignant control cells. Here, DNMT1 is linked to acute lymphoblastic leukemia.