We compared the above described MYC-driven T-ALL cells (EμSRα-tTA;tet-o-MYC) stably expressing a DNMT3B-specific shRNA (6780 3B-sh2) to cells harboring a scrambled shRNA (6780 SCR) as control (Figures 9 and 10 and Supplementary Figure 7). Here, MYC is linked to acute lymphoblastic leukemia.