To determine whether DNMT3B overexpression in T-ALL and Burkitt’s lymphoma cells is MYC-dependent, we took advantage of the tetracycline-regulated c-MYC allele in mouse T-ALL (EμSRα-tTA;tet-o-MYC) as well as in a human Burkitt’s lymphoma-like cell line model (P493-6). This evidence concerns the gene DNMT3B and acute lymphoblastic leukemia.