For that purpose, we turned to publically available ENCODE [32] Chip-seq and RNA-seq data sets for human Chronic Myeloid Leukemia (CML) (K562) and human embryonic stem cells (H1-hESCs) displaying the status of H3K27Ac, H3K4Me1, H3K4Me3 and MYC for the genomic loci of DNMT1, DNMT3A and DNMT3B (Figure 5 and Supplementary Figure 4). The gene discussed is DNMT3B; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.