MYC and Burkitt lymphoma: To determine whether DNMT3B overexpression levels in human B- and T-cell lymphoma cell lines depend on high levels of endogenous MYC, we analyzed a panel of human T-cell lymphoma and Burkitt’s lymphoma cell lines before and upon knock-down of MYC via tetracycline-inducible shRNA (Figure 6A, 6B and Supplementary Figure 5).