Knockout of DNMT3B accelerates the initiation of MYC-driven T- and B-cell lymphoma in mouse models (EμSRα-tTA;tet-o-MYC and Eμ-MYC) [48–50], while increased DNA methylation of DNMT3B targets delays leukemogenesis [51]. This evidence concerns the gene DNMT3B and B-cell non-Hodgkin lymphoma.