To unravel the role of DNA methyltransferases (DNMTs) in MYC-driven hematopoietic malignancies, we performed expression profiling for DNMT1, DNMT3A and DNMT3B comparing MYC-driven T-ALL and Burkitt’s lymphoma cells to non-malignant control cells. The gene discussed is MYC; the disease is acute lymphoblastic leukemia.