DNMT1 and chronic myelogenous leukemia, BCR-ABL1 positive: All three DNMT enzymes have been reported to be overexpressed in hematological malignancies such as acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), diffuse large B-cell lymphoma (DLBCL) as well as mantel cell lymphoma (MCL) [37–40].