To determine whether DNMT1 and DNMT3B transcription in T-ALL and Burkitt’s lymphoma-like cells is directly regulated by oncogenic MYC, we performed chromatin immunoprecipitation (ChIP) analysis measuring MYC binding to the genomic loci of DNMT1, DNMT3A and DNMT3B. This evidence concerns the gene DNMT3B and acute lymphoblastic leukemia.