The tetracycline-regulated MYC transgene in a mouse T-ALL (EμSRα-tTA;tet-o-MYC) and human Burkitt’s lymphoma (P493-6) model, allowed the time- and concentration-dependent inactivation of MYC, causing both DNMT1 and DNMT3B expression to decrease step-wise exhibiting a direct correlation with MYC levels. Here, MYC is linked to acute lymphoblastic leukemia.