The underlying mechanisms by which IL-6 promotes the carcinogenesis and progression of OC are extremely complex and multifactorial [33]; our findings that IL-6 along with IL-10 and possibly other mediators promotes the expansion of CD14+HLA-DR−/low MDSC provides an explanation for the increased presence of these immunosuppressive cells in the ascites and possible tumor tissues from OC patients thus adding another layer to the complex roles of IL-6. The gene discussed is IL10; the disease is neoplasm.