As shown in Supplementary Figure 4, combined IL-6 and IL-10 treatment induced a significant expansion of CD14+HLA-DR–/low MDSC which was dependent on STAT3 activation since STAT3 inhibitor Stattic abrogated this expansion; however, the extent of CD14+HLA-DR–/low MDSC expansion induced by combined IL-6 and IL-10 did not reach the level achieved by the AF from OC patients, indicating that other unidentified mediators existing in the ascites from OC patients may play a role in the production of these MDSC. The gene discussed is IL6; the disease is atrial fibrillation.