To further investigated correlations between the TERT and TERC polymorphisms and RCC susceptibility, we genotyped six SNPs in TERT and TERC genes: rs10936599 and rs35073794 on TERC; rs10069690, rs2242652, rs2853677 and rs285367 on TERT, and performed an association analysis to identify SNPs associated with RCC risk in Chinese Han population. This evidence concerns the gene TERC and renal cell carcinoma.