To further investigated correlations between the TERT and TERC polymorphisms and RCC susceptibility, we genotyped six SNPs in TERT and TERC genes: rs10936599 and rs35073794 on TERC; rs10069690, rs2242652, rs2853677 and rs285367 on TERT, and performed an association analysis to identify SNPs associated with RCC risk in Chinese Han population. The gene discussed is TERT; the disease is renal cell carcinoma.