TERC and cancer: Many studies have been performed to explore the associations between SNPs in the TERT and TERC genes and individual susceptibility to malignant tumors of the urinary system susceptibility, it is found that TERT rs2736100 AC genotype was associated with reduced risk of upper tract urothelial carcinomas [21], whereas AA genotype of rs2736098 was associated with an increased risk for RCC [22].