In a multivariate Cox proportional hazards ratio analysis adjusting for age, gender, cirrhosis, BCLC stage and serum AFP levels, we found that among the 24 integrin family genes, ITGA5, ITGB5 and ITGA2B were significantly associated with prognosis in terms of OS or RFS of patients with HBV-related HCC (Tables 5 and 6; P < 0.05). This evidence concerns the gene AFP and hepatocellular carcinoma.