Then, we compared the expression of ITGA5, ITGB5 and ITGA2B in 221 HBV-related HCC tissues and 221 adjacent normal tissues, and the results showed that ITGA5 and ITGB5 are more highly expressed in HBV-related HCC tissues than adjacent normal tissues, while ITGA2B had a lower expression level in HBV-related HCC tissues than adjacent normal tissues (Figure 3B; P < 0.001). The gene discussed is ITGA5; the disease is hepatocellular carcinoma.