In addition, this is the first study to detect the prognostic predictive value of combining the expression of ITGA5 with ITGB5. Finally, we found that the AG/GG genotypes at rs988574 (ITGA1) are significantly associated with better OS compared with carriers of the AA genotype in HBV-related HCC patients. This evidence concerns the gene ITGA5 and hepatocellular carcinoma.