Cox proportional hazards regression analysis showed that rs988574 was significantly associated with prognosis when adjusting for age, gender, race, smoking status, drinking status, BMI, child-Pugh class, cirrhosis, BCLC stage, pathological grade, TACE status post hepatectomy, antiviral therapy after hepatectomy, radical resection and serum AFP levels (Tables 2 and 3). The gene discussed is AFP; the disease is Cirrhosis.