In summary, our study demonstrated that the expression of ITGA5, ITGB5 and ITGA2B, as well as the genotype at rs988574 (ITGA1), may be potential independent prognostic bio-markers and therapeutic targets for HBV-related HCC patients and may be useful in the diagnosis of HBV-related HCC patients. Here, ITGA1 is linked to hepatocellular carcinoma.