In the current study, label free quantitative proteomics analysis of 1E7-03 in CEM T cells showed that the expression of Sds22 is downregulated by 1E7-03 treatment during HIV-1 infection, suggesting that expression of Sds22 may change the cellular distribution of PP1 and potentially deregulate translocation of PP1 between cytoplasm and nucleus thus impacting PP1 availability for Tat recruitment and CDK9 dephosphorylation. The gene discussed is TAT; the disease is HIV-1 infection.