As p53 regulates the cellular expression level of MDM2 and we wanted to assess whether DCN affect p53 function and stability through direct modulation of MDM2 expression in cancer cells, p53-null cell line Hep3B was used to compare the effect of dE1 and dE1/DCN on cellular MDM2 expression level without interference by endogenous p53. Here, MDM2 is linked to cancer.