BCL2 and neoplasm: CREB has been found to be a critical regulator of cell differentiation and involved in tumor progression and prognosis, supporting its role as a proto-oncogene [37] CREB can be activated through phosphorylation by a number of kinases, including Akt, p90Rsk, protein kinase A, and calcium/calmodulin-dependent kinases and controls genes that promotes tumor progression including Egr-1, Bcl-2 family members, and cyclins.