To evaluate the antiproliferative effects of ipatasertib and taselisib as single agents or in combination with anti-microtubule chemotherapic agents, we used several human breast cancer cell models, including PI3Kα/Akt mutation negative and PI3Kα/Akt mutation positive cell lines, that have also different biologic profiles, according to the expression of HER2 and HR, as indicated in Table 1. Here, AKT1 is linked to breast carcinoma.