A significant reduction of Ki-67 positive cells was identified in tumor sections from the nude mice undergoing treatment with HPEI+FILIP1LΔC103-p or DDP alone when contrasted against 5%GS or E-p, whereas the most substantial reduction of Ki-67 positive cells occurred in tumor sections from the nude mice undergoing treatment with HPEI+FILIP1LΔC103-p plus DDP in comparison with FILIP1LΔC103-p or DDP alone (Figure 4, P<0.01 vs. FILIP1LΔC103-p). The gene discussed is MKI67; the disease is neoplasm.