Since has 2 ligands, VEGF-A and PlGF [18], it is expected that the Flt-1 on CRC cells may interact with each other through VEGF/Flt-1 and/or PlGF/Flt-1-mediated signaling in a combined autocrine and paracrine way, to modulate cancer-associated vascularization and invasion. The gene discussed is FLT1; the disease is cancer.