On the other hand, Flt-1 on CRC cells may also use these signaling pathways to crosstalk with tumor endothelial cells and inflammatory cells, to mediate not only vascularization-related biological and pathological events, but also cellular signal cascades to alter cell phenotype, control cell transformation, cell proliferation, cell apoptosis, cell migration and inflammation [18]. Here, FLT1 is linked to neoplasm.