In addition to poor survival, patients with GC showing low BUB1 expression had a significantly higher tumor stage (p < 0.001), higher rates of lymph node metastases (p = 0.027) and distant metastases (p = 0.006) and a significantly higher UICC stage (p < 0.001), which may be another reason for the poor survival in this group and may suggest closer clinical follow up of patients, whose tumors show low BUB1 expression. The gene discussed is BUB1; the disease is neoplasm.