Interestingly, high BUB1 expression in tumors of patients receiving neoadjuvant chemotherapy (>28% of tumor nuclei) was associated with a shorter overall survival by Kaplan-Meier analysis compared to patients with tumors with BUB1 expression in less than 28% of tumor nuclei (log-rank test, p = 0.028). Here, BUB1 is linked to neoplasm.