Feng et al. reported that upregulation of SIRT6 was required for TGF-β1/H2O2/HOCl to promote the tumorigenicity of HCC cells owing to that suppression of SIRT6 expression could abrogate the promoting effects of TGF-β1/H2O2/HOCl on the tumorigenicity of HCC cells [23]. Here, SIRT6 is linked to hepatocellular carcinoma.