JAK2 and Splenomegaly: Regarding to the clinical and prognostic implications of the 5 SNPs in MPN patients, our results showed that MPN patients harbored the risk alleles of rs12343867_C (JAK2 46/1) and rs12339666_T (JAK2 intron 8) were more likely to have splenomegaly at diagnosis and were less likely to encounter hemorrhagic complications.