We noted upregulated KRT8 expression in ccRCC tissues with metastasis (Supplmentary Figure 1A) and with advanced clinic stages (III-IV) (Supplmentary Figure 1B), higher pT stages (III-IV) (Supplmentary Figure 1C) and worse Fuhrman grades (III-IV) (Supplmentary Figure 1D). The gene discussed is KRT8; the disease is nonpapillary renal cell carcinoma.