To confirm that IL-11 is regulated by KRT8 in human ccRCC tissues, we measured IL-11 mRNA levels in the above mentioned set of 109 pairs of tumor and matched primary NT tissues, as shown in Figure 1A, and found that IL-11 mRNA levels were significantly higher in the tumor tissues than in the primary NT tissues (Figure 5E). Here, KRT8 is linked to nonpapillary renal cell carcinoma.