We combined western blotting and RT-PCR analysis to determine that KRT8 can increase IL-11 expression, cause IL-11 autocrine induction, and activate IL-11/STAT3 signaling, findings that were verified further in our in vitro system, our xenograft metastasis model, and clinical ccRCC tissues. The gene discussed is IL11; the disease is nonpapillary renal cell carcinoma.