We combined western blotting and RT-PCR analysis to determine that KRT8 can increase IL-11 expression, cause IL-11 autocrine induction, and activate IL-11/STAT3 signaling, findings that were verified further in our in vitro system, our xenograft metastasis model, and clinical ccRCC tissues. This evidence concerns the gene STAT3 and nonpapillary renal cell carcinoma.