We explored the molecular mechanisms that potentially underlie ccRCC progression and metastasis further and found that the expression levels of EMT-related genes, such as E-cadherin, N-cadherin, and vimentin, were not significantly affected by KRT8, indicating that KRT8-mediated renal cancer cell metastasis is an EMT-independent process. The gene discussed is KRT8; the disease is nonpapillary renal cell carcinoma.