In chronic myeloid leukemia (CML), the activity of the constitutively active tyrosine kinase BCR-ABL1 [the product of the t(9;22)(q34;q11) chromosome translocation arising in hematopoietic stem cells of the bone marrow] drives the activation of the PI3K/AKT, JAK/STAT, and RAS/RAF/MEK/ERK pathways. The gene discussed is AKT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.