IFIH1 and dermatomyositis: According to the detection method, the overall OR showed that the presence of anti-MDA5 antibody was significantly associated with RPILD risk in DM patients in immunoprecipitation assays that compared 95 DM with RPILD and 423 DM without RPILD from eleven publications (OR = 20.31, 95% CI: 11.03–37.39, P < 0.001), as well as in ELISA assays that compared 80 DM with RPILD and 261 DM without RPILD from seven publications (OR = 31.86, 95% CI: 14.82–68.46, P < 0.001).