The pooled sensitivity, specificity and area under the curve of the summary receiver operating characteristic (AUC) values of anti-MDA5 antibody for DM with ILD versus without ILD were 0.47 (95% CI: 0.37–0.57), 0.96 (95% CI, 0.92–0.97), and 0.90 (95% CI: 0.88–0.93) (Figure 4), respectively. The gene discussed is IFIH1; the disease is dermatomyositis.