To test whether genotoxic stress modulates RECQ1 expression, we first measured RECQ1 mRNA levels in U2OS (osteosarcoma) cells that were either untreated or treated with etoposide (1 μM), doxorubicin (500 nM) or methylmethanesulfonate (MMS, 1 mM) for 4, 8 or 24 h (Figure 1A). The gene discussed is RECQL; the disease is osteosarcoma.