Furthermore, we first studied SNPs rs3730089 in the PIK3R1 gene and rs2699887 in the PIK3CA gene in melanoma patients, observing a trend of worse OS in homozygous recessive patients for the SNP rs2699887 in the PIK3CA gene vs. homozygous dominant and heterozygous genotypes. Here, PIK3R1 is linked to melanoma.