CD274 and cancer: In this context, Deng et al. showed that RT-mediated inflammation results in IFNγ release thus increasing PDL-1 expression on cancer cells, MDSCs, and M2-macrophages in tumor microenvironment [30] and also reported that the combination of RT and mAbs to PDL- 1 enhances the frequency of the abscopal events and the antitumor activity of both treatment modalities [30].