Concerning the Jagged2 ligand, the dysregulation is an early event occurring in the benign phase of monoclonal gammopathy of uncertain significance as a consequence of different genetic and epigenetic mechanisms [13,23] and play a key role in prompting bone marrow stromal cells to support myeloma cell growth by releasing key cytokines including IL-6, IGF-1, VEGF [17,24]. Here, JAG2 is linked to plasma cell myeloma.