SOD2 and neoplasm: Although chromosome 6q instability and loss of heterozygosity (LOH) have been reported in melanoma [64] and associated with low SOD2 expression during the process of SV40 fibroblast transformation [80], SOD2’s role as a tumor suppressor is most commonly associated with SOD2 expression decreases through SOD2 epigenetic regulation or inhibition of tumor associated signaling that affect the basal and enhancer transcriptional machinery.