SOD2 and renal carcinoma: Moreover, it was demonstrated that renal carcinoma cells display enhanced SOD2 oxidation at histidine (His54, His55), tyrosine (Tyr58) and tryptophan (Trp147, Trp149) residues [75], and human medulloblastoma cells have been previously shown to harbor hotspots for histidine (His54, His55) oxidation and SOD2 inactivation [48].