SOD2 polymorphisms, including isoleucine-to-threonine substitution at amino acid 58 (Ile58Thr), which destabilized tetramer formation, and leucine-to-phenylalanine at codon 60 (Leu60Phe), result in decreased SOD2 activity and have consequences on cancer malignancy [136,137,138,139]. This evidence concerns the gene SOD2 and cancer.