For instance, the presence of Treg cells, which are immunosuppressive, in the microenvironment of many solid tumors, and the importance of LFA-1 for the function of these cells [85,86], suggests that targeting LFA-1 would limit the function of Treg cells and improve the action of the immune system against the tumor [43,44]. This evidence concerns the gene ITGB2 and neoplasm.