CYP2D6 and acute myeloid leukemia: Additionally, neither AML enantiomer affected the activity of CYP1A (7-ethoxyresorufin O-deethylation), CYP2A6 (coumarin 7-hydroxylation), CYP2D6 (bufuralol 1′-hydroxylation), or CYP2E1 (chlorzoxazone 6-hydroxylation); in all these cases, the IC50 values for both AML enantiomers were above 50 μM (see Table 1 and Figure 2).