Through the use of a pituitary cDNA expression library, a large cohort of patients (86 with hypophysitis and 90 controls) was investigated and the pituitary gland-specific factor 1a (TPIT), was identified as auto-ag in 10.5% of patients with hypophysitis [37], while PGSF-1a and -2 and neuron-specific enolase, were also found, but at a frequency that did not differ from that of the healthy controls [37]. The gene discussed is TBX19; the disease is hypophysitis.