In the former conducted in human TNBC MDA-MB-231 and Hs578T and non-TNBC MCF-7 and BT474 tumor-bearing mice, anti-angiogenic treatment promoted cancer invasion via vasculogenic mimicry in the microcirculation of malignant tumors.HIF-1α, MMP2, VE-cadherin, and twist1 were expressed at a higher level in human TNBC compared with non-TNBC. This evidence concerns the gene HIF1A and neoplasm.