In fact, in stromal cells, altered caveolae with CAV1 expression loss, oxidative stress and aberrant crosstalk between oxidative stress, endothelial nitric oxide (eNO), HIFI-α, and NF-κB join with increased glycolysis, while in cancer cells, increased mitochondrial OXPHOS and cell proliferation prevail. The gene discussed is NFKB1; the disease is cancer.