In another experimental study [67], fructose-1,6-biphosphatase 1 (FBP1) was down-regulated in MDA-MB-468 basal-like cell line, and its over-expression under hypoxic condition was significantly associated with decreased tumor growth and migration as well as glycose consumption and lactate production likely through HIF-1α inhibition and reduced mRNA levels of pyruvate dehydrogenase kinase 1 (PDK1), lactate dehydrogenase A (LDHA), glucose transporter 1 (GLUT1), and vascular endothelial growth factor (VEGF). Here, PDK1 is linked to neoplasm.