Most compellingly, conditional gene deletion (or knockdown) demonstrates that MCL-1 is required for the sustained growth of AML driven by MLL-fusion genes,106 MYC-driven B lymphoma,107 TP53−/− thymic lymphoma,108 BCR-ABL-driven acute lymphoblastic leukaemia109 and myeloma.110. Here, MCL1 is linked to plasma cell myeloma.