In particular, most tumours (~90%) have mutations that inactivate the p53 protein, delete its gene or impair upstream regulators, preventing p53 induction of PUMA and NOXA to drive apoptosis.64 In addition, 17% of mantle cell lymphoma cell lines have homozygous deletions of BIM,65 and many Burkitt lymphomas harbour epigenetically silenced BIM or PUMA alleles.66, 67. This evidence concerns the gene TP53 and mantle cell lymphoma.