Pathway analysis using PANTHER42 on the 8,133 genes from the unpaired results showed significant enrichment in: (1) WNT signaling pathway (Bonferroni P adj = 7.49 × 10−8); (2) Angiogenesis (P adj = 4.12 × 10−4); (3) Alzheimer disease presenilin pathway (P adj = 4.79 × 10−4); (4) Cadherin signaling (P adj = 9.29 × 10−4); (5) Integrin signaling (P adj = 2.09 × 10−3); (6) Gonadotropin-releasing-hormone-receptor pathway (P adj = 3.65 × 10−3); (7) CCKR signaling (P adj = 6.22 × 10−3) (Table S5). The gene discussed is GNRHR; the disease is early-onset autosomal dominant Alzheimer disease.