Unfortunately, the symptoms are also shared by CD [3,14], irritable bowel syndrome (IBS) [4,5,14] and non-immunoglobulin E (IgE)-mediated food allergies [4,14,32,33,34], and, as for CD, symptoms must be considered a poor indicator and predictor of the disease [29,35,36]. Here, IGHE is linked to irritable bowel syndrome.