The TRR1-, TRR2-, TRR3-, Feno-, or Metf-treated mice show an increase in the expression levels of PPARα, but a decrease in expressions of FAS in the liver; and TRR1-, TRR2-, or TRR3-treated mice reduced the expression levels of PPARγ as compared with the HF mice (Figure 7A,B). The gene discussed is PPARA; the disease is hydrops fetalis.