As shown in Figure 2, the negative control (as the insulin + palmitate group) exhibited insulin resistance and hyperlipidemia, resembling the symptom in the liver of HFD-induced diabetic and hyperlipidemic mice—such mice have sufficient insulin but the peripheral tissues thereof are insensitive to insulin (the insulin + palmitate group were represented as insulin resistance and hyperlipidemia). Here, INS is linked to hyperlipidemia.