This work has extended to administration of HFD-fed mice with TRR for 4 weeks, with the finding that TRR increased the expressions of membrane GLUT4 in skeletal muscles (Figure 6) and enhanced expression levels of p-AMPK both in skeletal muscles and liver tissues (Figure 6), resulting in the improvement of both glycemic control and lipid profile, establishing TRR acts as an AMPK activator and promotes membrane glucose uptake with an increase in membrane GLUT4 expressions in the maintenance of euglycemia and normal lipidemia in a mouse model of type 2 diabetes and dyslipidemia. Here, SLC2A4 is linked to type 2 diabetes mellitus.