BDNF and Alzheimer disease: Rothman et al. reported that a triple-transgenic mouse model of AD (3xTgAD mice expressing mutant presenilin-1M146V, and amyloid precursor proteinSwe, and TauP301L) exhibited an elevated levels of hippocampal Aβ oligomers, increased plasma GCs, and decreased BDNF levels after chronic mild social stress, whereas such an elevated Aβ and decreased BDNF were not observed in control mice under the stress, indicating that the AD model animal is more vulnerable to the chronic stress [86].