ESR2 and hepatocellular carcinoma: In these in vitro studies at 72 h post-treatment, IGF2 significantly promoted cell proliferation in T47D (ERα+/ERβ+) cells, as well as in TNBC MDA-MB-231 and HCC 1937 cells (Figure 1; p < 0.05), and the action is significantly different from that in control cells.