LPL and obesity due to melanocortin 4 receptor deficiency: Lipid profile parameters of a significant difference in obese diabetic and non-diabetic subjects could be explained by the fact that the insensitivity of adipose cells and other target tissues to insulin (insulin resistance), clearly seen in obesity and T2DM, results in dysregulation of enzymes such as lipoprotein lipase, resulting in elevated and extended lipemia due to the failure to rapidly clear plasma triglycerides.