IL6 and obesity due to melanocortin 4 receptor deficiency: However, the clear demarcation between these marker levels in obese diabetics in comparison to obese non-diabetics provides evidence for a positive association between hs-CRP, IL-6 and TNF-α levels and T2DM among our studied population, and also that this association was independent of BMI and WC, suggesting that this elevation might not be limited to obesity alone in this population.