These cytokines induce insulin resistance in insulin target tissues by activating the suppressors of cytokine signaling proteins; several kinases such as c-Jun N-terminal kinase, IκB kinase β, and protein kinase C; inducible nitric oxide synthase, extracellular signal-regulated kinase, and protein tyrosine phosphatases such as protein tyrosine phosphatase 1B [11]. Here, INS is linked to Insulin resistance.