The observations that the presence of liver cirrhosis is no discriminating parameter concerning OS, and that a therapy-associated decrease of the unfavorable prognostic parameter, CRP concentration in serum, is significantly associated with improved OS, suggest the assumption that the administered biomodulatory therapy may induce anakoinosis that means, decisively reprograms tumor-promoting functions provided by the cirrhotic liver and neighboring tumor microenvironment [7]. The gene discussed is CRP; the disease is cirrhosis of liver.