The molecular alterations in IDH-wildtype glioblastomas include mutations in the TERT promoter [24], chromosome 10q loss, 7p gain or EGFR amplification, (some with an additional EGFR vIII mutation), ID2, MYCN and PDGFRA amplifications and CDKN2A/B deletions [45]. Here, IDH2 is linked to glioblastoma.